How to Treat a Mosquito Bite. I’m one of those unlucky people who always get a big, itchy swelling from a mosquito bite. I got, oh, only a dozen of them from the cottage weekend. The biggest one is conveniently located on — wait for it — my middle finger. It’s so swollen I can hardly bend it. Right now I’m on the ibuprofen/topical antibiotic combo to get rid of the swelling. No improvement so far. I’m about ready to try another trick. Do you have any tips?